General Information

During different stages of human development NRP1 tissue specific expression changes. Ensembl has a specific section for gene expression, and within that section the gene expression is broken down into expression at different developmental stages (10). For NRP1 Ensembl specifically listed developmental stages of the brain post conception. NRP1 gene expression 9 weeks post conception was highest in the pons, with an expression level of 82 TPM, and next was the spinal cord at 53 TPM. Other notable expression areas of the brain at 9 weeks post conception are the basal ganglion, diencephalon, midbrain, medulla oblongata, midbrain, and telencephalon, all of which had expression above 20 TPM. Later on at 16 weeks post conception, NRP1 is highly expressed in the hippocampus, with an expression level of 130 TPM. Also, in this stage the expression in the brain fragment, midbrain, and pons are all above 30 TPM. At an even later development stage, 19 weeks post conception the NRP1 expression is only in the brain fragment with an expression level of 59 TPM. Although Ensembl only provided detailed development stages for the brain it also provided data for NRP1 expression in the fetal human proteome (10). Interestingly, the brain was not where the highest NRP1 expression was located; the fetal heart had the highest expression level. This fetal proteome also revealed that NRP1 is expressed in the gut, liver, and testis during human development.